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Kamagra is a drug for the treatment of erectile dysfunction, characterized by the inability to achieve or maintain an erection of the penis sufficient for satisfactory intercourse. Kamagra is effective only in the presence of sexual stimulation.
Kamagra should be taken as needed about an hour before sexual intercourse. The recommended dose of the drug is 50 mg and is taken before meals. After taking the drug on an empty stomach, the effect occurs after 30 minutes. When taking sildenafil in combination with fatty foods, the absorption rate decreases. Based on the effectiveness and tolerability of the drug, its dose can be increased to 100 mg or reduced to 25 mg. The maximum recommended dose of the drug is 100 mg. The maximum recommended frequency of taking the drug is 1 time per day.
Sildenafil citrate is a potent and selective inhibitor of type 5 cGMP-specific phosphodiesterase (PDE5). The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the cavernous bodies during sexual stimulation. Nitric oxide activates the enzyme guanylate cyclase, which leads to an increase in the level of cyclic guanosine monophosphate (cGMP), relaxation of the smooth muscles of the cavernous body and increased blood flow in the penis. During sexual arousal, local excretion of NO by sildenafil leads to inhibition of PDE5 and an increase in cGMP in the cavernous body. This leads to relaxation of smooth muscles and an increase in blood flow in the cavernous body of the penis and persistent erection.